레이블이 Discount Supplements Canada인 게시물을 표시합니다. 모든 게시물 표시
레이블이 Discount Supplements Canada인 게시물을 표시합니다. 모든 게시물 표시

2013년 11월 24일 일요일

About 'vitamin canada'|... and how other staff would find it hard to work with a transgender.” [Canada] Trans bride files human rights complaint against wedding...







About 'vitamin canada'|... and how other staff would find it hard to work with a transgender.” [Canada] Trans bride files human rights complaint against wedding...








H1N1               flu               vaccines               in               Canada               are               being               produced               with               a               special               chemical,               called               an               adjuvant,               that               boosts               the               effectiveness               of               the               shot.

According               to               the               NIAID               this               is               generally               done               for               one               of               three               reasons:               "1)               to               boost               the               immune               response               in               certain               age               groups               or               in               people               with               underlying               health               conditions               who               can               not               mount               an               adequate               immune               response               to               a               vaccine               made               without               adjuvant;               2)               to               broaden               the               immune               response               to               a               vaccine               to               provide               better               protection               against               a               virus               if               it               mutates;               and               3)               to               stretch               the               vaccine               supply               if               it               is               limited."("NIAID               trials               of               2009               H1N1               influenza               vaccines               plus               adjuvant")               One               of               the               reasons               to               use               an               adjuvant               for               H1N1               vaccine               production               was               that               the               virus               apparently               doesn't               reproduce               well               in               eggs,               the               medium               used               for               growing               the               vaccine               culture.

While               the               United               States               went               ahead               with               a               non-adjuvanted               vaccine               after               studies               showed               that               only               one               dose               would               provide               effective               protection,               Canada's               vaccine               producer               GlaxoSmithKline               (GSK)               opted               to               add               its               own               proprietary               adjuvant               called               AS03.

This               choice               was               made               partially               to               speed               up               vaccine               production               after               initial               problems               were               encountered,               but               also               in               reaction               to               requests               from               the               World               Health               Organization               to               use               "'antigen               sparing               strategies'               to               stretch               supplies."               ("Frequently               asked               questions               about               the               swine               flu               vaccine")
               What               is               AS03?
               AS03               is               an               oil-in-water               suspension               based               on               squalene,               a               natural               substance               produced               in               the               human               body.

It               also               contains               DL-α-tocopherol               (vitamin               D)               and               polysorbate-80,               the               same               stabilizer               that               keeps               your               salad               dressing               and               ice               cream               from               separating.

Squalene               is               used               in               cosmetic               products               as               an               emollient               that               is               easily               absorbed               by               the               skin.

In               vaccinations               squalene               prompts               the               production               of               C4               memory               cells,               which               in               turn               promotes               a               stronger               immune               response.
               Using               a               squalene-based               adjuvant               such               as               AS03               -               or               MF59               which               has               been               in               European               flu               shots               since               1997               -               can               make               it               possible               to               produce               an               effective               vaccine               using               only               one-fourth               the               usual               amount               of               antigen.

It               is               also               a               factor               in               making               vaccines               that               contain               only               the               protein               or               fragments               of               protein,               rather               than               a               weakened               or               killed               pathogen               as               was               traditionally               done               in               creating               vaccines.

("Benefit               and               doubt               in               vaccine               additive")
               Adjuvanted               Vaccines               Longer               to               Approve
               While               some               vaccines               are               made               to               protect               against               a               single               source               of               illness               that               doesn't               change               much               over               time,               influenza               is               constantly               mutating.

It               is               for               this               reason               that               seasonal               flu               shots               must               be               given               each               year:               the               trends               are               analyzed               from               year               to               year               and               a               vaccine               is               made               to               protect               against               the               three               strains               predicted               to               be               the               most               prevalent               in               the               upcoming               flu               season.

Every               year               a               different               combination               of               strains               is               present               in               the               flu               shot,               so               every               year               those               who               want               to               be               vaccinated               need               a               new               shot.

The               basic               procedure               used               to               make               the               vaccine               remains               the               same               however,               which               allows               health               officials               to               go               through               the               approval               process               more               quickly.
               Because               there               have               never               been               any               adjuvanted               influenza               vaccines               used               in               Canada               approval               cannot               be               "fast-tracked;"               therefore               the               new               H1N1               vaccine               is               taking               longer               to               approve               than               would               a               seasonal               flu               vaccine.
               The               vaccines               in               the               United               States               are               non-adjuvanted,               and               probably               one               of               the               reasons               these               were               chosen               was               to               speed               up               the               approval               process               in               order               to               get               vaccines               out               to               the               public               more               quickly.

Judging               from               the               difference               in               severity               of               outbreaks               between               Canada               and               the               United               States,               this               seems               to               have               been               a               wise               decision.
               Safety               of               Oil-in-Water               Adjuvants
               Over               40               million               people               have               safely               received               MF59-adjuvanted               influenza               vaccine               over               a               period               of               more               than               a               decade.

AS03               has               been               tested               on               45,000               people.

It               does               tend               to               increase               local               reactions               at               the               site               of               injection,               but               adjuvants               in               this               class               are               not               associated               with               any               other               side               effects               in               humans.

("Vaccine               Safety               -               Questions               and               Answers")
               The               decision               to               order               non-adjuvanted               vaccine               for               pregnant               women               and               young               children               in               Canada               is               based               on               recommendations               of               the               World               Health               Organization.

This               is               due               to               the               fact               that               squalene-based               adjuvants               have               mainly               been               used               in               vaccines               administered               to               adults               over               age               65,               and               there               is               no               data               available               on               safety               in               expectant               mothers               or               very               young               children.

Non-adjuvanted               vaccine               will               therefore               be               reserved               for               this               population               in               particular.
               Availability               of               the               Non-Adjuvanted               Vaccine               in               Canada
               Recent               announcements               indicate               that               the               AS03               adjuvanted               H1N1               vaccine               manufactured               by               GlaxoSmithKline               will               shortly               be               approved               in               Canada,               and               that               distribution               of               the               vaccine               will               begin               almost               immediately               thereafter.

"Pre-positioning"               of               the               vaccine,               shipping               to               the               provinces               in               advance               of               approval,               will               make               this               possible.

The               non-adjuvanted               vaccine,               however,               has               not               yet               been               shipped               or               approved.

All               indications               are               that               pregnant               women               who               want               the               non-adjuvanted               vaccine               will               have               to               wait               in               line               a               while               longer,               despite               the               fact               that               they               were               identified               as               being               among               those               who               were               most               in               need               of               the               H1N1               vaccine.
               Pregnant               women               should               discuss               vaccination               with               their               health               care               provider,               as               WHO               recommendations               did               not               rule               out               using               adjuvanted               vaccine               if               the               non-adjuvanted               version               was               not               available.

Health               Canada               officials               point               out               that               some               countries               are               vaccinating               everyone               with               adjuvanted               vaccine.

They               recommend               expectant               mothers               go               ahead               and               take               whatever               vaccine               is               available,               as               soon               as               possible.

Pregnant               women               were               recently               identified               as               one               of               three               groups               at               highest               risk               for               severe               illness               or               death               from               swine               flu.

The               other               groups               are               children               under               age               two,               and               people               with               chronic               respiratory               illnesses               such               as               asthma.
               In               Quebec,               pregnant               women               may               also               be               advised               to               apply               for               preventive               leave               in               order               to               protect               themselves               and               their               unborn               babies.

H1N1               influenza               will               not               cross               the               placenta,               but               the               respiratory               symptoms               in               pregnant               women               are               more               severe               than               in               the               general               population,               and               this               can               have               negative               repercussions               for               the               pregnancy.
               Related               Stories:
               H1N1               Vaccines               Available               in               Canada               Earlier               Than               Expected               |               Pregnant               Women               and               H1N1:               Quebec               Offers               Preventive               Leave
               Sources:
               "AS03"               Wikipedia
               "Adjuvant               effect               on               H1N1               vaccine"               Vincent               Racaniello               (Virology               Blog)
               "Benefit               and               doubt               in               vaccine               additive"               Andrew               Pollack               (New               York               Times)
               "Conflicting               advice               offered               to               pregnant               women               on               H1N1               vaccine"               Maria               Babbage               (Canadian               Press)
               "Frequently               asked               questions               about               the               swine               flu               vaccine"               Angela               Mulholland               &               Dr.

Neil               Rau               (CTV               News)
               "H1N1               vaccine               approval               expected               this               week"               Meagan               Fitzpatrick               (Canwest               News)
               "H1N1               vaccines               for               pregnant               women               not               yet               ready"               Meagan               Fitzpatrick               (Canwest               News)
               "H1N1:               To               vaccinate               or               not               to               vaccinate?"               Aaron               Derfel               (The               Gazette)
               "NIAID               trials               of               2009               H1N1               influenza               vaccines               plus               adjuvant"               National               Institute               of               Allergy               and               Infectious               Diseases
               "Pregnant               Ont.

women               face               H1N1               vaccine               delay"               CBC               News
               "Safety               of               squalene"               World               Health               Organization
               "Squalene"               Wikipedia
               "Vaccine               Safety               -               Questions               and               Answers"               City               of               Ottawa






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